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KMID : 1007520090180051204
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Food Science and Biotechnology
2009 Volume.18 No. 5 p.1204 ~ p.1211
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Modulation of Nrf2/ARE and Inflammatory Signaling Pathways by Hericium erinaceus Mycelia Extract
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Jin Kyoung-Suk
Park Ji-Young
Cho Mi-Kyung
Jang Ji-Hyun
Jeong Jae-Han
Ok Seon
Bak Min-Ji
Song Young-Sun
Kim Myo-Jeong
Cho Chung-Won
Jeong Woo-Sik
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Abstract
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Hericium erinaceus is an edible mushroom used as a medicinal food in Asian countries. In this study, the chemopreventive effects of H. erinaceus mycelia hot water extract (HEW) were evaluated. HEW remarkably induced the luciferase activity of the antioxidant response element (ARE), located in the promoter region of phase 2 and antioxidant genes and regulated by nuclear factor E2-related factor 2 (Nrf2). The up-regulation of ARE activity by HEW corresponded with the induction of Nrf2 and the antioxidant enzyme, hemeoxygenase-1. The inhibition of cyclooxygenase-2 (COX-2) activity is a promising effective approach in cancer chemoprevention, and HEW prominently suppressed COX-2 protein expression in HepG2 cells. Furthermore, HEW showed anti-inflammatory activity by modulating inflammatory mediators such as nitric oxide (NO), inducible NO synthase, tumor necrosis factor-α, interleukin-1β, and the transcription factor, nuclear factor-κB, in lipopolysaccharide-stimulated RAW 264.7 cells. These results suggest that H. erinaceus possessed anti-tumor and antiinflammatory effects via the modulation of Nrf2/ARE and inflammatory signaling pathways, and may therefore have potential use as a natural chemopreventive agent.
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KEYWORD
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Hericium erinaceus mycelia, antioxidant response element (ARE), nuclear factor E2-related factor 2 (Nrf2), antiinflammation, chemoprevention
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